New gene linked to Alzheimer's disease identified
Researcher, including one of Indian-origin, have discovered an immune system gene associated with higher rates of amyloid plaque, a hallmark of...
New York: Researcher, including one of Indian-origin, have discovered an immune system gene associated with higher rates of amyloid plaque, a hallmark of Alzheimer's disease.
The research found that a variant in the IL1RAP gene was associated with greater amyloid plaque accumulation over two years and had an even stronger effect than the well-known APOE e4 allele which is notorious for its association with the development of Alzheimer's disease.
Using positron emission tomography imaging in nearly 500 individuals, the researchers assessed the levels of brain amyloid deposits at an initial visit and again two years later.
A genome-wide analysis was then conducted to identify genetic variants associated with the rate of plaque accumulation during this two-year window.
As predicted, APOE e4 was found to be associated with higher rates of plaque buildup. However, the investigators were surprised to find that IL1RAP showed an independent and even stronger influence on amyloid accumulation.