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Evidence should inform policy: Should we offer antiretroviral therapy soon after HIV diagnosis?
There are over 1 million new TB cases in people living with HIV (PLHIV) and 320,000 HIV/TB deaths every year. Moreover HIV increases the risk of getting TB manifold - PLHIV have an annual 5%-15% risk of acquiring TB infection as against is 5%-15% lifetime risk in HIV negative persons.
There are over 1 million new TB cases in people living with HIV (PLHIV) and 320,000 HIV/TB deaths every year. Moreover HIV increases the risk of getting TB manifold - PLHIV have an annual 5%-15% risk of acquiring TB infection as against is 5%-15% lifetime risk in HIV negative persons.
Challenges to concurrent HIV and TB therapy - like pill burden, overlapping drug toxicities, pharmacokinetic of drug-drug interactions, increased risk of immune restoration disease - have led to debates on when to initiate ART in patients with newly diagnosed HIV infection and TB. However, results of a few important studies produce strong evidence to improve treatment outcomes for PLHIV as well as to protect them from co-infections like TB.
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