Tel Aviv: Israeli Defence Minister Israel Katz has threatened Iran’s Supreme Leader on Thursday after the latest missile barrage from Iran damaged the main hospital in southern Israel and hit several other residential buildings near Tel Aviv. Israel, meanwhile, struck a heavy water reactor that is part of Iran’s nuclear program.

At least 240 people were wounded by the Iranian missiles, four of them seriously, according to Israel’s Health Ministry.

The vast majority were lightly wounded, including more than 70 people from the Soroka Medical Centre in the southern city of Beersheba, where smoke rose as emergency teams evacuated patients.

In the aftermath of the strikes, Katz blamed Iran’s Supreme Leader Ayatollah Ali Khamenei and said the military “has been instructed and knows that in order to achieve all of its goals, this man absolutely should not continue to exist.”

Israel carried out strikes on Iran’s Arak heavy water reactor, in its latest attack on the country’s sprawling nuclear program.

The conflict began last Friday with a surprise wave of Israeli airstrikes targeting military sites, senior officers and nuclear scientists. A Washington-based Iranian human rights group said at least 639 people, including 263 civilians, have been killed in Iran and more than 1,300 wounded. In retaliation, Iran has fired over 400 missiles and hundreds of drones, killing at least 24 people in Israel and wounding hundreds.